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Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Our Company's Future Talent Program features internships that last 10-12 weeks and may include one or more projects. For you: these positions in our Research & Development Division will provide you with a great development opportunity and a chance to see if we are the right company for your long-term goals. For us: we get to meet the best and brightest individuals who represent the future of scientific endeavor in the US.

We are seeking candidates with a passion for scientific research, excellent academic performance, communication skills, teamwork, and the ability to work in a multi-functional environment. A strong science background in applied laboratory settings, computer science or cheminformatics is essential. Applicants with previous research experience in the listed areas are highly preferred. You will be provided with laptops/lab equipment etc. as necessary to perform the role. This is a paid internship targeted to start in June 2025 and run for 10-12 weeks. Potential involvement in a scientific publication may occur as a result of the research undertaken during the internship.

The department of Discovery Biologics is offering internships in the following disciplines:

Protein Analytical Characterization

The candidate will be using various analytical protein characterization techniques to characterize biologics, support protein engineering initiatives and help guide candidate selection for development. The candidate will be involved in implementing new analytical methods for protein characterization and developability assessment of biologics modalities (monoclonal antibodies, bispecifics, antibody and protein scaffolds, antibody-drug-conjugates. Prior experience with methods such as SEC, HIC, RP, DSF, SPR, ELISA and automation would be beneficial. The candidate will learn how to characterize biologics, interpret data, optimize protocols and develop new methods to help support protein engineering and biologics candidate selection. Intern will be exposed to many areas of research relevant to the drug discovery and development process.

Mass Spectrometry

The candidate will be using various Mass Spectrometry-based methods to characterize biologics to support protein sciences core activities and enable biologics candidate selection for progression to development. The candidate will be involved in developing new mass spectrometry methodologies for biologics characterization (antibodies, bispecifics, fusion proteins, and bioconjugates). The position requires candidates being passionate about developing analytical methods. Prior experience with protein characterization using LC-MS and familiarity with different ionization methods (e.g., CID, ETD, HCD, and UVPD) is strongly preferred.

The candidate will learn how to characterize biologics, interpret data, optimize protocols and develop new methods to help support protein engineering and biologics candidate selection. Intern will be exposed to many areas of research relevant to the drug discovery and development process.

Biologics Engineering, Expression, Purification

The candidate will work to support biologics discovery by using some or all of the following methods: molecular biology, protein design, protein engineering (sequence-based, structure-based and AI-ML-guided ), protein expression in mammalian cells (transient, stable cell lines), protein purification (using various chromatographic support and chemistries such as affinity, ion-exchange, hydrophobic, size-exclusion chromatography) and characterization using methods including SDS-PAGE, CE-SDS, SEC, and etc. Interns will be exposed to many areas of research relevant to the drug discovery and development process.

Antibody generation

The candidate will work on antibody discovery, functional and epitope characterization of antibody lead candidates across multiple disease areas, development of new platforms, and methods to increase sequence and functional diversity of hit molecules.

Biologics Design & Display

The candidate will use computational methods combined with yeast and phage display to identify and engineer novel therapeutic proteins. Interns working in this group will gain experience in a broad range of techniques from molecular biology, microbiology, and protein engineering.

Biologics Automation & Capabilities

The candidate will use and help develop advanced automation and novel capabilities such as microfluidics to enable and enhance the discovery and engineering of biologics. Interns will gain experience in a broad range of automation skills as applied to the discovery biologics pipeline. Prior experience with automation is not required. Students will also learn the fundamentals of molecular biology, cell culture, and protein design and production.

Biologics Characterization with cell-based assays

The candidate will leverage functional cell-based assays and biophysical measurements to evaluate biologics hits and leads for engineering efforts. Student will gain hands on experience with techniques to measure protein-protein interactions and/or cell-based function assays to enable protein engineering and help guide candidate molecule selection.

Gene & Cell Therapy

The candidate will work on the development of novel mRNA and cell-based therapies such as CAR T cell therapies. Students working in this group will gain experience in modern cell engineering methods to develop CAR T cell therapies.

Discovery Biologics Interns will collaborate with a wide spectrum of discovery biologics, therapeutic area biology and drug discovery experts across our company. Students will have the opportunity to join a breadth of existing discovery projects and will be expected to initiate their own pilot project opportunities.

Interns will be responsible for accurate electronic notebook recording, safe laboratory practices, and presentation of data and their interpretation to a team of scientists. The intern will also attend departmental and team meetings to gain a wider perspective of the drug development process in the pharmaceutical industry.

Locations: South San Francisco, CA; Boston, MA; Cambridge, MA

*Please note when applying for this position, if the applicant is selected for an interview, he/she must be prepared to submit letters of recommendation, a brief research statement, and a copy of his/her transcript. Applicant must select location when applying for this position *

Required:

• Pursuing BS/BA or Master’s/Ph.D. degree in related field with demonstrated interest/experience in research areas relevant to the drug discovery process.

• Basic laboratory skills and research experience such as: protein biochemistry, biophysics molecular biology, protein expression and purification, protein characterization using biochemical and biophysical techniques, and safe lab practices.

• Must have completed at least two years of studies toward BS/BA degree or at least 1 year towards Master’s/PhD at time of internship (Summer 2024).

• Must be currently enrolled in an academic program at the time of the application and be continuing education for at least 1 semester once internship completes (Fall 2025).

• Must be available for full-time employment for 10-12 weeks during the months of June - August 2025.

• Champion for diverse and inclusive culture.

Preferred:

• Expertise in computational protein engineering and machine learning with substantial expertise in predictive protein and antibody structure and significant interest in applying modeling/informatics methods towards drug discovery research.

• Experience with protein engineering, protein expression in mammalian cells and purification.

• Experience with mammalian cell culture and in vitro functional assays.

• Past experience characterizing proteins using techniques such as HPLC/UPLC (SEC, HIC, RP), CE-SDS, SPR, MS analysis is preferred.

• GPA of 3.0 or higher.

Under New York City, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

$39,600.00-$105,500.00

FTP2025

MRL2025

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088_EEOC_KnowYourRights_10_20.pdf)

EEOC GINA Supplement​

Pay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp_%20English_formattedESQA508c.pdf)

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Intern/Co-op (Fixed Term)

Relocation:

No relocation

VISA Sponsorship:

No

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

11/15/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R311396